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Comment Randomized Controlled Trial Multicenter Study
In Enterobacterales bacteremia, antipseudomonal β-lactam de-escalation was noninferior to continuation for clinical cure at 3 to 5 d.
- Konstantinos Ouranos and Eleftherios Mylonakis.
- Houston Methodist Hospital, Houston, Texas, USA (K.O., E.M.).
- Ann. Intern. Med. 2024 May 1; 177 (5): JC52JC52.
AbstractLópez-Cortés LE, Delgado-Valverde M, Moreno-Mellado E, et al; SIMPLIFY study group. Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial. Lancet Infect Dis. 2024;24:375-385. 38215770.
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