• J Headache Pain · May 2024

    Review

    Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.

    • Jaisan Islam, Md Taufiqur Rahman, Elina Kc, and Young Seok Park.
    • Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju, Korea.
    • J Headache Pain. 2024 May 10; 25 (1): 7676.

    AbstractTrigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of the insular cortex (IC) is thought to involve several neuroplastic changes in multiple brain regions, resulting in distorted pain perception and associated comorbidities. While the functional changes in the insula are recognized contributors to TNP, the intricate mechanisms underlying the involvement of the insula in TNP processing remain subjects of ongoing investigation. Here, we have overviewed the most recent advancements regarding the functional role of IC in regulating TNP alongside insights into the IC's connectivity with other brain regions implicated in trigeminal pain pathways. In addition, the review examines diverse modulation strategies that target the different parts of the IC, thereby suggesting novel diagnostic and therapeutic management of chronic TNP in the future.© 2024. The Author(s).

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