• Tommy Nguyen, Mo Mai, Amulya Choudhary, Slavic Gitelman, Jefferson Drapkin, Antonios Likourezos, Sarah Kabariti, Rukhsana Hossain, Karina Kun, Ankit Gohel, Patrizia Niceforo, Michael Silver, and Sergey Motov.
• Department of Emergency Medicine Maimonides Medical Center, Brooklyn, NY.
• Ann Emerg Med. 2024 Oct 1; 84 (4): 354362354-362.

Study ObjectiveWe aimed to assess and compare the analgesic efficacy and adverse effects of intravenous subdissociative-dose ketamine to nebulized ketamine in emergency department (ED) patients with acute painful conditions.MethodsWe conducted a prospective, randomized, double-blind, double-dummy clinical trial in adult patients (ages 18 and older) with a numerical rating scale pain score of ≥5. We randomized subjects to receive either a single dose of 0.3 mg/kg of intravenous (IV) ketamine or 0.75 mg/kg of nebulized ketamine through a breath-actuated nebulizer. Primary outcome was the difference in pain scores on the numerical rating scale between groups at 30 minutes postmedication administration. The secondary outcomes included the need for rescue analgesia, occurrences of adverse events in each group, and the difference in pain scores at 15, 30, 60, 90, and 120 minutes. We calculated a 95% confidence interval (CI) for a mean difference at 30 minutes, with a minimum clinically important difference set at 1.3 points.ResultsWe enrolled 150 subjects (75 per group). Mean pain scores through numerical rating scale were 8.2 for both groups at baseline, which decreased to 3.6 and 3.8 at 30 minutes, yielding a mean difference of 0.23 (95% CI -1.32 to 0.857). We observed no clinically concerning changes in vital signs. No serious adverse events occurred in any of the groups throughout the study period.ConclusionWe found no difference between the administration of IV and nebulized ketamine for the short-term treatment of moderate to severe acute pain in the ED, with both treatments providing a clinically meaningful reduction in pain scores at 30 minutes.Copyright © 2024 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

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