• Annals of medicine · Dec 2024

    Review

    The role of gonadal hormones in regulating opioid antinociception.

    • Qi Xu, Lin Jin, LuYang Wang, YingYing Tang, Hui Wu, Qing Chen, and LiHong Sun.
    • Department of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
    • Ann. Med. 2024 Dec 1; 56 (1): 23292592329259.

    AbstractOpioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical studies have reported strong evidence for sex-related divergence regarding opioid analgesia. There is an increasing amount of evidence indicating that gonadal hormones regulate the analgesic efficacy of opioids. This review presents an overview of the importance of gonadal steroids in modulating opioid analgesic responsiveness and focuses on elaborating what is currently known regarding the underlyingmechanism. We sought to identify the link between gonadal hormones and the effect of oipiod antinociception.

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