• Xavier Waltz, Marc Romana, Marie-Dominique Hardy-Dessources, Yann Lamarre, Lydia Divialle-Doumdo, Marie Petras, Vanessa Tarer, Régine Hierso, Kizzy-Clara Baltyde, Benoît Tressières, Marie-Laure Lalanne-Mistrih, Fréderic Maillard, Olivier Hue, Maryse Etienne-Julan, and Philippe Connes.
• UMR Inserm 665, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe, France ; Laboratoire ACTES (EA 3596), Département de Physiologie, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe,  France ; Laboratory of Excellence GR-Ex "The red cell: from genesis to death", PRES Sorbonne Paris Cité, Paris, France.
• Plos One. 2013 Jan 1;8(10):e77830.

AbstractThe six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.

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