• Yi-Ling Dai, Ling Xiao, Zhen Pan, Guo-Qian He, Ju Gao, Xia Guo, and Zhuo Huang.
• Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
• Medicine (Baltimore). 2024 May 10; 103 (19): e38148e38148.

RationaleParaneoplastic neurological syndrome with anti-Hu antibody (Hu-PNS) is a neurological disorder that occur in patients with malignancy. The syndrome has a wide range of presentations and can present before diagnosis of primary malignancy. Familiarity with these paraneoplastic neurological syndromes can help early recognition and take appropriate regimens.Patients ConcernsDiagnosis and treatment of Hu-PNS.DiagnosesThis is retrospective study that analyzed the clinical data of this case. Through retrospective analysis and targeted antibody screening, serum anti-Hu antibody was detected. Subsequent spinal imaging revealed a mass in the paraspinal region, which was confirmed as ganglioneuroblastoma by pathologic examination.InterventionsThe child was treated with a course of intravenous immunoglobulin and radical surgical operation without chemotherapy.OutcomesThe neurological symptoms were gradually improved and no signs indicate disease progression or tumor recurrence.LessonsHu-PNS has rarely been reported in children with ganglioneuroblastomas. They can mimic non-neoplastic processes, making detection and diagnosis difficult. Serum and/or cerebrospinal fluid onconeural antibody can strongly indicate occult cancers. Early detection of paraneoplastic neurological syndromes can help take appropriate regimens and improve prognosis.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

17 keywords...

hide…