• Internal medicine · May 2024

    Neuropsychiatric Systemic Lupus Erythematosus in a Patient with Pancytopenia and Chronic Schizophrenia Requiring Hospitalisation.

    • Taro Horino, Satoshi Inotani, Masahiro Komori, Hiroshi Ohnishi, and Yoshio Terada.
    • Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Japan.
    • Intern. Med. 2024 May 16.

    AbstractWe herein report a patient with systemic lupus erythematosus (SLE) and neuropsychiatric SLE (NPSLE), who had been misdiagnosed with schizophrenia for a long time and presented with pancytopenia. Brain magnetic resonance imaging revealed sporadic punctate hyperintense areas in the cerebral white matter. Single-photon emission computed tomography revealed a clear decrease in blood flow from the parietotemporal association area to the temporal lobe. NPSLE is a serious organ complication that significantly worsens the SLE prognosis. NPSLE symptoms are diverse and difficult to diagnose and differentiate from those of other neuropsychiatric disorders, especially in an early onset.

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