• Internal medicine · Jan 2024

    Case Reports

    Successful Treatment of Ultrasound-confirmed Synovitis in Anti-MDA5 Antibody-positive Clinically Amyopathic Dermatomyositis with Corticosteroid Therapy.

    • Kenji Saito, Jumpei Temmoku, Yuya Sumichika, Shuhei Yoshida, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Toru Yago, Shuzo Sato, and Kiyoshi Migita.
    • Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.
    • Intern. Med. 2024 Jan 1; 63 (10): 147314781473-1478.

    AbstractAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis (CADM) is a subtype of dermatomyositis without severe myositis but with characteristic cutaneous manifestations and severe interstitial lung disease. Joint symptoms can occur in patients with anti-MDA5 antibody-positive CADM. However, the treatment strategy and utility of ultrasound for treating joint symptoms remain unknown. We herein report an 85-year-old man with anti-MDA5 antibody-positive CADM who presented with ultrasound-confirmed synovitis that improved with medium-dose corticosteroid therapy.

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