• Mohammad Rostami Nejad, Kamran Rostami, Yoshio Yamaoka, Reza Mashayekhi, Mahsa Molaei, Hossein Dabiri, David Al Dulaimi, Dariush Mirsattari, Homayoun Zojaji, Mohsen Norouzinia, and Mohammad Reza Zali.
• Research Institute of Gastroenterology and Liver Disease, Shahid Beheshti University, M.C., Tehran, Iran.
• Arch Iran Med. 2011 Mar 1; 14 (2): 115118115-8.

BackgroundCeliac disease has been reported to be associated with gastric abnormalities. The aim of this study was to assess the relationship between the prevalence of celiac disease and Helicobacter pylori infection in an Iranian population of 250 patients.MethodsBiopsies were taken from the gastric antrum and duodenum. Morphology and histology were evaluated using the updated Sydney system and modified Marsh criteria, respectively. To simplify the interpretation of gastric lesions we classified gastritis in macroscopic and microscopic stages. Serology for anti-tissue transglutaminase antibody was performed to determine the presence of celiac disease.ResultsAmong 250 patients, 232 (93%) had histological evidence of Helicobacter pylori infection. Histological abnormalities (Marsh I to IIIc) were present in 24 (10%). Of 24 patients, 20 (83%) with histological abnormalities were infected with Helicobacter pylori. Of 250 patients, 25 (10%) had a positive anti-tissue transglutaminase antibody. Of 25 anti-tissue transglutaminase antibody positive patients, 9 (3.6%) had microscopic and macroscopic enteritis (Marsh I to IIIc).ConclusionsClinical presentation of celiac disease was not distinguishable from cases infected with Helicobacter pylori. Histology, even in patients with positive serology, was non-specific and unhelpful. We found a high prevalence of Helicobacter pylori infection and chronic gastritis, but neither was associated with celiac disease, in agreement with studies in Western populations.

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