• Semin Respir Crit Care Med · Jun 2024

    Review

    Novel Therapeutic Approaches in Connective Tissue Disease-Associated Interstitial Lung Disease.

    • Erica Mulcaire-Jones, Janelle Vu Pugashetti, Justin M Oldham, and Dinesh Khanna.
    • Division of Rheumatology, Internal Medicine, University of Michigan, Ann Arbor, Michigan.
    • Semin Respir Crit Care Med. 2024 Jun 1; 45 (3): 435448435-448.

    AbstractConnective tissue diseases (CTD) comprise a group of autoimmune diseases that can affect multiple organs in the body including the lungs. The most common form of pulmonary involvement is interstitial lung disease (ILD). CTD-associated ILD (CTD-ILD) can take one of several courses including nonprogressive, chronically progressive, or rapidly progressive. Chronically and rapidly progressive patterns are associated with increased mortality. Limited randomized controlled trial data are available for treatment of CTD-ILD, with most data coming from systemic sclerosis-related ILD. The current first-line treatment for all CTD-ILD is immunosuppression with consideration of antifibrotics, stem cell transplant, and lung transplant in progressive disease. In this article, we review data for ILD treatment options in systemic sclerosis, rheumatoid arthritis, myositis, and primary Sjögren's syndrome-related ILDs.Thieme. All rights reserved.

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