• KhanQudsia UmairaQUCMH Lahore Medical College, Lahore, Pakistan., Muneeb Ur Rehman, Mohammad Ali Arshad Abbasi, Rubina Rafique Shiekh, Munazza Nazir, Sohail Khan Raja, Amna Akbar, Sabahat Tasneem, Sarosh Khan Jadoon, and Sarosh Alvi.
• CMH Lahore Medical College, Lahore, Pakistan.
• Medicine (Baltimore). 2024 May 17; 103 (20): e38197e38197.

BackgroundThe association between allergies and cancer is contradictory, whereas some forms of cancer have inverse associations with allergies. Allergic rhinitis (AR) is the most prevalent form of allergy, and lung cancer is one of the most prevalent forms of cancer with the highest mortality rate. Recent studies have reported a positive association between asthma and lung cancer; however, this association is inconclusive. Furthermore, AR is positively associated with asthma; therefore, our research question was to explore whether there is any correlation between AR and lung cancer epidemiologically.MethodsAfter a rigorous search of PubMed, Google Scholar, and ScienceDirect, 7 eligible articles were included in this systematic review and meta-analysis, including 4724 cases and 9059 controls, 5 from the USA, and one each from Canada and Germany.ResultsPooled analysis (OR, 0.55; 95% CI: 0.45-0.68; P value < .00001) showed a strong inverse relationship between AR and lung cancer.ConclusionThe current meta-analysis suggests an inverse relationship between AR and lung cancer; however, new epidemiological studies are required to observe the current scenario more comprehensively.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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