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Review
Clinical research progress on intrathecal glucocorticoids in the treatment of infections: A review.
- Zixv Lv and Yingying Liu.
- Department of Pain, Zibo First Hospital, Zibo, Shandong, China.
- Medicine (Baltimore). 2024 May 17; 103 (20): e38123e38123.
AbstractIn some infectious diseases, pathogenic microorganisms can directly or indirectly cause significant inflammatory reactions in the central nervous system, leading to severe neurological dysfunction, such as suppurative meningitis, tuberculous meningitis, and febrile infections. related epilepsy syndrome, etc. In these diseases, adjuvant administration of glucocorticoids is necessary to inhibit the release of proinflammatory cytokines, and intrathecal administration can deliver the drug more directly to the target. In this article, the authors studied intrathecal glucocorticoids for the treatment of infectious inflammatory reactions in terms of pharmacological effects and mechanisms, pharmacokinetics, clinical application, and safety. The authors concluded that the article could help provide new treatment strategies for infectious diseases.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
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