• Lorraine B Ware, D Clark Files, Alpha Fowler, Michael S Aboodi, Neil R Aggarwal, Roy G Brower, Steven Y Chang, Ivor S Douglas, Scott Fields, Andrea S Foulkes, Adit A Ginde, Estelle S Harris, Gregory W Hendey, R Duncan Hite, Weixing Huang, Poying Lai, Kathleen D Liu, B Taylor Thompson, Michael A Matthay, and National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network.
• Vanderbilt University Medical Center, Nashville, Tennessee.
• JAMA. 2024 Aug 6; 332 (5): 390400390-400.

ImportanceAcetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates.ObjectiveTo determine whether acetaminophen increases days alive and free of organ dysfunction in sepsis compared with placebo.Design, Setting, And ParticipantsPhase 2b randomized, double-blind, clinical trial conducted from October 2021 to April 2023 with 90-day follow-up. Adults with sepsis and respiratory or circulatory organ dysfunction were enrolled in the emergency department or intensive care unit of 40 US academic hospitals within 36 hours of presentation.InterventionPatients were randomized to 1 g of acetaminophen intravenously every 6 hours or placebo for 5 days.Main Outcome And MeasuresThe primary end point was days alive and free of organ support (mechanical ventilation, vasopressors, and kidney replacement therapy) to day 28. Treatment effect modification was evaluated for acetaminophen by prerandomization plasma cell-free hemoglobin level higher than 10 mg/dL.ResultsOf 447 patients enrolled (mean age, 64 [SD, 15] years, 51% female, mean Sequential Organ Failure Assessment [SOFA] score, 5.4 [SD, 2.5]), 227 were randomized to acetaminophen and 220 to placebo. Acetaminophen was safe with no difference in liver enzymes, hypotension, or fluid balance between treatment arms. Days alive and free of organ support to day 28 were not meaningfully different for acetaminophen (20.2 days; 95% CI, 18.8 to 21.6) vs placebo (19.6 days; 95% CI, 18.2 to 21.0; P = .56; difference, 0.6; 95% CI, -1.4 to 2.6). Among 15 secondary outcomes, total, respiratory, and coagulation SOFA scores were significantly lower on days 2 through 4 in the acetaminophen arm as was the rate of development of acute respiratory distress syndrome within 7 days (2.2% vs 8.5% acetaminophen vs placebo; P = .01; difference, -6.3; 95% CI, -10.8 to -1.8). There was no significant interaction between cell-free hemoglobin levels and acetaminophen.Conclusions And RelevanceIntravenous acetaminophen was safe but did not significantly improve days alive and free of organ support in critically ill sepsis patients.Trial RegistrationClinicalTrials.gov Identifier: NCT04291508.

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