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Yonsei medical journal · Jun 2009
ReviewEpigenetic regulation of cytokine gene expression in T lymphocytes.
- Choong-Gu Lee, Anupama Sahoo, and Sin-Hyeog Im.
- Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500-712,Korea.
- Yonsei Med. J. 2009 Jun 30; 50 (3): 322330322-30.
AbstractThe developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic mechanisms. The principal events, signaling pathways and the lineage determining factors involved have been extensively studied in the past ten years. Recent studies have elucidated the important role of chromatin remodeling and epigenetic changes for proper regulation of gene expression of lineage-specific cytokines. These include DNA methylation and histone modifications in epigenomic reprogramming during T helper cell development and effector T cell functions. This review discusses the basic epigenetic mechanisms and the role of transcription factors for the differential cytokine gene regulation in the T helper lymphocyte subsets.
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