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Yonsei medical journal · Nov 2011
Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study.
- Young-Chul Yoo, Jin Hwan Oh, Tae Dong Kwon, Yeong Kyu Lee, and Sun Joon Bai.
- Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Yonsei Med. J. 2011 Nov 1; 52 (6): 101610211016-21.
PurposeWe investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats.Materials And MethodsOne hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA.ResultsIn the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group.ConclusionThe analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
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