• Anja Lindén, M Spångfors, M H Olsen, J Fisher, G Lilja, F Sjövall, M Jungner, M Lengquist, T Kander, L Samuelsson, J Johansson, E Palmnäs, J Undén, J Oras, M Cronhjort, M Chew, A Linder, M Lipcsey, N Nielsen, J C Jakobsen, P Bentzer, and REDUSE Trial Group.
• Anesthesiology and Intensive Care, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. anja.linden.icu@gmail.com.
• Crit Care. 2024 May 17; 28 (1): 166166.

Background/PurposeNon-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypothesis that a restrictive protocol targeting non-resuscitation fluids reduces the overall volume administered compared with usual care.MethodsAdults with septic shock in six Swedish ICUs were randomized within 12 h of ICU admission to receive either protocolized reduction of non-resuscitation fluids or usual care. The primary outcome was the total volume of fluid administered within three days of inclusion.ResultsMedian (IQR) total volume of fluid in the first three days, was 6008 ml (interquartile range [IQR] 3960-8123) in the restrictive fluid group (n = 44), and 9765 ml (IQR 6804-12,401) in the control group (n = 48); corresponding to a Hodges-Lehmann median difference of 3560 ml [95% confidence interval 1614-5302]; p < 0.001). Outcome data on all-cause mortality, days alive and free of mechanical ventilation and acute kidney injury or ischemic events in the ICU within 90 days of inclusion were recorded in 98/98 (100%), 95/98 (98%) and 95/98 (98%) of participants respectively. Cognition and health-related quality of life at six months were recorded in 39/52 (75%) and 41/52 (79%) of surviving participants, respectively. Ninety out of 134 patients (67%) of eligible patients were randomized, and 15/98 (15%) of the participants experienced at least one protocol violation.ConclusionProtocolized reduction of non-resuscitation fluids in patients with septic shock resulted in a large decrease in fluid administration compared with usual care. A trial using this design to test if reducing non-resuscitation fluids improves outcomes is feasible.Trial RegistrationClinicaltrials.gov, NCT05249088, 18 February 2022. https://clinicaltrials.gov/ct2/show/NCT05249088.© 2024. The Author(s).

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