• Br J Anaesth · Jun 2024

    Editorial

    Improved outcome with individualised antifibrinolytic therapy: what is the evidence?

    • Daniel Bolliger and Marco Ranucci.
    • Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, University of Basel, Basel, Switzerland. Electronic address: daniel.bolliger@usb.ch.
    • Br J Anaesth. 2024 Jun 1; 132 (6): 118711891187-1189.

    AbstractViscoelastic haemostatic testing (VHT) has been used to determine hyperfibrinolysis and hypofibrinolysis. When modified by addition of tissue plasminogen activator (tPA), VHT has been suggested to assess responses to antifibrinolytic therapy and to estimate the concentration of tranexamic acid in patients undergoing cardiac surgery. Despite some evidence that tPA-modified VHT might allow individualisation of antifibrinolytic therapy, further studies are warranted to prove its clinical benefit for postsurgical bleeding, transfusion of blood products, and thromboembolic events.Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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