• Jinfeng Zhan, Yujie Rao, Jiahao Liu, Haizhou Miao, and Zhongbin Xia.
• Health Management Medicine Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
• Intern Emerg Med. 2024 Aug 1; 19 (5): 135313581353-1358.

AbstractTo investigate the potential causal relationship between ulcerative colitis and nephrotic syndrome. We obtained the whole-genome association study data of ulcerative colitis in the European population from the GWAS database. Relevant single nucleotide polymorphisms (SNPs) were selected for analysis. We employed the inverse variance-weighted meta-analysis of multiplicative random effects models to obtain SNP-specific Wald ratio estimates, which assume horizontal pleiotropy. In addition, we performed sensitivity analyses using MR-Egger, weighted median, and IVW. Our findings suggest a strong association between ulcerative colitis and nephrotic syndrome (P < 0.05). After conducting sensitivity analyses, we found no evidence of horizontal pleiotropy or heterogeneity (P > 0.05). This study provides evidence for an association between ulcerative colitis and nephrotic syndrome, which may help us better understand the conditions of ulcerative colitis and nephropathy.© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).

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