• Donguk Park, Jonghan Leem, Kyoungmu Lee, Heungkyu Lim, Yeyong Choi, Jong-Ju Ahn, Sinye Lim, Jeongim Park, Kyungho Choi, Naroo Lee, Hyejung Jung, Jongsik Ha, and Domyung Paek.
• Department of Environmental Health, Korea National Open University, 169 Dongsung-dong, Jongno-gu, Seoul 110-791, Republic of Korea. pdw545@gmail.com.
• Environ Health Glob. 2014 Jan 1;13:70.

BackgroundThis study describes 17 families with 38 lung injury patients (14 males, 24 females; 22 preschool-age children less than six years of age and 16 individuals of 13-50 years) who used disinfectant added to humidifiers in the home.MethodsClinical examination and humidifier disinfectant-use histories were taken, and a thorough home investigation was performed to assess exposure to humidifier disinfectant.ResultsNine of the patients (three pregnant females, six preschool-age children) died soon after they first developed lung damage. Six (16%) were pregnant females and 22 (58%) were preschool-aged children younger than six years. The patients used humidifier disinfectant products containing either polyhexamethylene guanidine phosphate (PHMG, n = 36) or oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride (PGH, n = 2). Twenty-six patients (68%) used the brand "Oxy"®, which contains PHMG. Of the ten patients with fatal lung injury, nine were found to have used PHMG.ConclusionsOur findings suggest that the use of humidifier disinfectant products containing either PGH or PHMG can cause lung injury, especially in preschool-age children younger than six years and pregnant women.

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