• Cochrane Db Syst Rev · Jun 2015

    Review

    Snake antivenom for snake venom induced consumption coagulopathy.

    • Kalana Maduwage, Nick A Buckley, H Janaka de Silva, David G Lalloo, and Geoffrey K Isbister.
    • School of Medicine and Public Health, University of Newcastle, C/O Calvary Mater Newcastle, Waratah, NSW, Australia, 2294.
    • Cochrane Db Syst Rev. 2015 Jun 9; 2015 (6): CD011428CD011428.

    BackgroundSnake venom induced consumption coagulopathy is a major systemic effect of envenoming. Observational studies suggest that antivenom improves outcomes for venom induced consumption coagulopathy in some snakebites and not others. However, the effectiveness of snake antivenom in all cases of venom induced consumption coagulopathy is controversial.ObjectivesTo assess the effect of snake antivenom as a treatment for venom induced consumption coagulopathy in people with snake bite.Search MethodsThe search was done on 30 January 2015. We searched the Cochrane Injuries Group's Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid OLDMEDLINE(R), Embase Classic+Embase (OvidSP), three other sources, clinical trials registers, and we also screened reference lists.Selection CriteriaAll completed, published or unpublished, randomised, controlled trials with a placebo or no treatment arm, where snake antivenom was administered for venom induced consumption coagulopathy in humans with snake bites.Data Collection And AnalysisTwo authors reviewed the identified trials and independently applied the selection criteria.Main ResultsNo studies met the inclusion criteria for this review.Authors' ConclusionsRandomised placebo-controlled trials are required to investigate the effectiveness of snake antivenom for clinically relevant outcomes in patients with venom induced consumption coagulopathy resulting from snake bite. Although ethically difficult, the routine administration of a treatment that has a significant risk of anaphylaxis cannot continue without strong evidence of benefit.

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