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- Zhen-Yuan Tan, Yuan Lou, Yu-Cui Qin, Wei Lin, Bin-Bin Liang, Suren R Sooranna, Yi-Li Ma, and Su-Fang Zhou.
- School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
- Int J Med Sci. 2024 Jan 1; 21 (6): 107910901079-1090.
AbstractIdiopathic pulmonary fibrosis (IPF) is a rare, chronic and progressively worsening lung disease that poses a significant threat to patient prognosis, with a mortality rate exceeding that of some common malignancies. Effective methods for early diagnosis and treatment remain for this condition are elusive. In our study, we used the GEO database to access second-generation sequencing data and associated clinical information from IPF patients. By utilizing bioinformatics techniques, we identified crucial disease-related genes and their biological functions, and characterized their expression patterns. Furthermore, we mapped out the immune landscape of IPF, which revealed potential roles for novel kinase 1 and CD8+T cells in disease progression and outcome. These findings can aid the development of new strategies for the clinical diagnosis and treatment of IPF.© The author(s).
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