-
- Xiaochuan Wang, Zibo Gao, Kai Chen, Chengyu Huang, and Yongjin Li.
- The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
- World Neurosurg. 2024 Aug 1; 188: e81e92e81-e92.
BackgroundDiabetes mellitus (DM) has been related to a higher risk of intervertebral disc degeneration (IVDD). However, the previous studies showed inconsistent results. We performed a systematic review and meta-analysis to comprehensively investigate the association between DM and IVDD in adult population.MethodsObservational studies relevant to the aim of the meta-analysis were retrieved by search of electronic databases including PubMed, Web of Science, and Embase. A random-effects model was used to combine the data by incorporating the influence of between-study heterogeneity.ResultsEleven observational studies involving 2,881,170 adults were included. Among them, 1,211,880 had DM. Compared to those with normoglycemia, patients with DM were associated with a higher odds ratio of IVDD (OR: 1.68, 95% confidence interval: 1.24 to 2.29, P<0.001; I2=98%). Further sensitivity analysis excluding database studies with IVDD diagnosed via International Classification of Diseases codes showed consistent results (odds ratio: 1.47, 95% confidence interval: 1.06 to 2.02, P=0.02) with no statistical heterogeneity (I2=0%). Subgroup analyses showed a stronger association between DM and IVDD in cohort studies than that in cross-sectional studies, in studies evaluating overall IVDD than that evaluating lumbar disc degeneration, and in studies that adjusted age and body mass index than that did not (P for subgroup differences all <0.05). Subgroup analyses according to study country and quality score did not significantly affect the association.ConclusionsDM may be associated with IVDD in adult population, which seems to be independent of age and body mass index.Copyright © 2024 Elsevier Inc. All rights reserved.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.