• World Neurosurg · Aug 2024

    Multicenter Study

    The Clinical and Radiological Outcomes of the Multimodal Use of The Woven EndoBridge (WEB) Device: A Large Multicentre Study.

    • Mohamed Nasra, Davor Pavlin-Premrl, Sara Protto, Ali Khabaza, Calvin Gan, Paul Siasat, Ashu Jhamb, Paul Smith, Justin Moore, Jeremy Russell, Yifan Ren, Lee-Anne Slater, Ronil V Chandra, Winston Chong, Behnam Shaygi, Mark Brooks, Julian Maingard, and Hamed Asadi.
    • Department of Medicine, Northern Health, Melbourne, Victoria, Australia. Electronic address: mohamedjim.nasra@monashhealth.org.
    • World Neurosurg. 2024 Aug 1; 188: e168e176e168-e176.

    BackgroundThe Woven EndoBridge (WEB) is a device used for intrasaccular flow diversion, designed for the elimination of wide-necked bifurcation aneurysms from the circulation. In this study, we aim to assess the safety and efficacy of the WEB and its uses in treating aneurysms of different morphologies and locations.MethodsIn a retrospective analysis, we compiled a comprehensive dataset from patients treated with the WEB device across three major Australian neurovascular centers from May 2017 to September 2023. The case series encompassed a spectrum of aneurysm types, including wide-necked bifurcation, sidewall, and irregularly shaped aneurysms, as well as cases previously managed with alternative therapeutic strategies. This study additionally encompasses cases where aneurysms were managed using the WEB device in combination with supplementary endovascular devices.ResultsThe study included 169 aneurysms in 161 patients. The rate of satisfactory aneurysm occlusion was 85.6%, with 86.7% of patients maintaining good functional status at their most recent follow-up. The procedure exhibited a low mortality rate of 0.6% and a thromboembolic complication rate of 7.1% (n = 12/161). There were no instances of postoperative re-rupture and the procedure-related hemorrhage rate was low (1.2%, n = 2/169), aligning with the literature regarding the safety and efficacy of the WEB device.ConclusionsOur multicenter trial reinforces the WEB device's role as an effective and safe modality for intracranial aneurysm management, supporting its expanded application beyond wide-necked bifurcation aneurysms. Further prospective studies are required to delineate its evolving role fully.Copyright © 2024 Elsevier Inc. All rights reserved.

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