• Dtsch. Med. Wochenschr. · Jun 2024

    Review

    [Current Standards in the Treatment of Hodgkin Lymphoma].

    • Johannes C Hellmuth.
    • Medizinische Klinik und Poliklinik III, LMU Klinikum, LMU München, München, Germany.
    • Dtsch. Med. Wochenschr. 2024 Jun 1; 149 (12): 702708702-708.

    AbstractThis review discusses current trends in the treatment of Hodgkin lymphoma, focusing on optimizing therapy outcomes while minimizing toxicity. We summarize advances made by the incorporation of Brentuximab Vedotin into first line therapy for advanced stage Hodgkin lymphoma. Similarly, the incorporation of checkpoint-inhibition into first-line therapy holds great promise and early results suggest superior efficacy with reduced toxicity. In relapsed or refractory Hodgkin lymphoma, salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation remains the standard approach. However, the remarkable efficacy of checkpoint inhibition in this setting has the potential to redefine treatment paradigms and obviate the need for HD-ASCT in select patients. Finally, we discuss the evolving landscape of nodular lymphocyte predominant Hodgkin lymphoma and reclassification to nodular lymphocyte predominant B-cell lymphoma, with increasing recognition of its distinct characteristics and treatment strategies.Thieme. All rights reserved.

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