• World Neurosurg · Aug 2024

    Reconsideration and Reflection on Spinal Disorders through the Study of Intervertebral Discs in Patients with Lumbar Spondylolisthesis.

    • Haoran Li, Hengrui Chang, Kaiyu Liu, Zhuang Zhang, Wei Xu, Xinghua Zhou, Lin Zhu, Jian Zhao, Di Zhang, and Xianzhong Meng.
    • The Spinal Surgery Department of the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; Hebei Medical University, Shijiazhuang, Hebei, China.
    • World Neurosurg. 2024 Aug 1; 188: e326e333e326-e333.

    ObjectiveThis study analyzed and explored the relationship between isthmic spondylolisthesis and disc degeneration by comparing the degree of disc degeneration in patients with isthmic spondylolisthesis, lumbar disc herniation, and asymptomatic healthy individuals.MethodsThis study included a total of 138 cases, consisting of L5-S1 single segment lesion patients and a normal lumbar spine population. The cases were divided into 3 groups based on the type of disease: fifty eight cases in the isthmic spondylolisthesis (IS) group, 50 cases in the lumbar disc herniation (LDH) group, and 30 cases in the normal lumbar vertebrae (NLV) group.ResultsThe research findings indicate that the proportion of intervertebral disc degeneration in the LDH group is significantly higher than that in the IS group and NLV group (65.3% vs. 33.3% vs. 25.8%, P < 0.05). The Pfirrmann grades of lumbar intervertebral discs (L1-L4) in the LDH group are significantly higher than those in the IS group and NLV group (P < 0.05), and the intervertebral height index (IHI) (L1-L4) of lumbar vertebrae in the LDH group is significantly lower than that in the IS group and NLV group (P < 0.05).ConclusionsThe results showed that the degree of intervertebral disc degeneration in patients with isthmic spondylolisthesis was lighter than that in patients with LDH, and even similar to that in healthy individuals. The occurrence of IS may have slowed down the degeneration of nonaffected segment intervertebral discs through certain factors.Copyright © 2024 Elsevier Inc. All rights reserved.

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