• M Antonelli, G Conti, M Bufi, M G Costa, A Lappa, M Rocco, A Gasparetto, and G U Meduri.
• Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Rome, Italy. max.antonelli@flashnet.it
• JAMA. 2000 Jan 12;283(2):235-41.

ContextNoninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure.ObjectiveTo compare NIV with standard treatment using supplemental oxygen administration to avoid endotracheal intubation in recipients of solid organ transplantation with acute hypoxemic respiratory failure.Design And SettingProspective randomized study conducted at a 14-bed, general intensive care unit of a university hospital.PatientsOf 238 patients who underwent solid organ transplantation from December 1995 to October 1997, 51 were treated for acute respiratory failure. Of these, 40 were eligible and 20 were randomized to each group.InterventionNoninvasive ventilation vs standard treatment with supplemental oxygen administration.Main Outcome MeasuresThe need for endotracheal intubation and mechanical ventilation at any time during the study, complications not present on admission, duration of ventilatory assistance, length of hospital stay, and intensive care unit mortality.ResultsThe 2 groups were similar at study entry. Within the first hour of treatment, 14 patients (70%) in the NIV group, and 5 patients (25%) in the standard treatment group improved their ratio of the PaO2 to the fraction of inspired oxygen (FIO2). Over time, a sustained improvement in PaO2 to FIO2 was noted in 12 patients (60%) in the NIV group, and in 5 patients (25%) randomized to standard treatment (P = .03). The use of NIV was associated with a significant reduction in the rate of endotracheal intubation (20% vs 70%; P = .002), rate of fatal complications (20% vs 50%; P = .05), length of stay in the intensive care unit by survivors (mean [SD] days, 5.5 [3] vs 9 [4]; P = .03), and intensive care unit mortality (20% vs 50%; P = .05). Hospital mortality did not differ.ConclusionsThese results indicate that transplantation programs should consider NIV in the treatment of selected recipients of transplantation with acute respiratory failure.

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