• BrownKilian G MKGMDepartment of Colorectal Surgery and Surgical Outcomes Research Centre, Royal Prince Alfred Hospital, Sydney, Australia., Michael J Solomon, Cherry E Koh, Paul A Sutton, Samuel Aguiar, Tiago S Bezerra, Hamish W Clouston, Ashwin Desouza, Eric J Dozois, Amanda L Ersryd, Frank Frizelle, Jonas A Funder, Julio Garcia-Aguilar, Richard Garfinkle, Tamara Glyn, Alexander Heriot, Yukihide Kanemitsu, Chia Y Kong, Helle Ø Kristensen, Songphol Malakorn, David M Mens, Per J Nilsson, Gabriella J Palmer, Emmanouil Pappou, Martha Quinn, Aaron J Quyn, Chucheep Sahakitrungruang, Avanish Saklani, Arne M Solbakken, Jim P Tiernan, Cornelis Verhoef, and Daniel Steffens.
• Department of Colorectal Surgery and Surgical Outcomes Research Centre, Royal Prince Alfred Hospital, Sydney, Australia.
• Ann. Surg. 2024 May 15.

ObjectiveTo establish globally applicable benchmark outcomes for pelvic exenteration (PE) in patients with locally advanced primary (LARC) and recurrent rectal cancer (LRRC), using outcomes achieved at highly specialised centres.Background DataPE is established as the standard of care for selected patients with LARC and LRRC. There are currently no available benchmarks against which surgical performance in PE can be compared for audit and quality improvement.MethodsThis international multicentre retrospective cohort study included patients undergoing PE for LARC or LRRC at 16 highly experienced centres between 2018 and 2023. Ten outcome benchmarks were established in a lower-risk subgroup. Benchmarks were defined by the 75th percentile of the results achieved at the individual centres.Results763 patients underwent PE, of which 464 patients (61%) had LARC and 299 (39%) had LRRC. 544 patients (71%) who met predefined lower risk criteria formed the benchmark cohort. For LARC patients, the calculated benchmark threshold for major complication rate was ≤44%; comprehensive complication index (CCI): ≤30.2; 30-day mortality rate: 0%; 90-day mortality rate: ≤4.3%; R0 resection rate: ≥79%. For LRRC patients, the calculated benchmark threshold for major complication rate was ≤53%; CCI: ≤34.1; 30-day mortality rate: 0%; 90-day mortality rate: ≤6%; R0 resection rate: ≥77%.ConclusionsThe reported benchmarks for PE in patients with LARC and LRRC represent the best available care for this patient group globally and can be used for rigorous assessment of surgical quality and to facilitate quality improvement initiatives at international exenteration centres.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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