• Br J Anaesth · Dec 2024

    Editorial Review

    The safety of nitrous oxide: glass half-full or half-empty?

    • Philip J Peyton and Kate Leslie.
    • Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia, Austin Health, Melbourne, VIC, Australia. Electronic address: phil.peyton@austin.org.au.
    • Br J Anaesth. 2024 Dec 1; 133 (6): 135813621358-1362.

    AbstractA systematic review of clinical trials confirms that including nitrous oxide in the gas mixture for general anaesthesia has minor short-term benefits and does not impact most patient safety outcomes. However, no risk-benefit analysis of nitrous oxide should ignore its known environmental effects. If continued nitrous oxide use is supported, strategies to minimise and monitor the contribution of medical nitrous oxide to global warming are vital.Copyright © 2024 British Journal of Anaesthesia. All rights reserved.

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