• Internal medicine · May 2024

    Erdheim-Chester Disease with Pancreatic Enlargement Observed Using Contrast-enhanced Endoscopic Ultrasonography.

    • Akihiro Maruyama, Takahiro Nishikawa, Asuka Nagura, Takuya Kurobe, Jun Yashika, Yuho Nimura, Raimei Ko, Tomohiro Yamaguchi, Kazuki Saito, Kazuhiro Yoshida, Iori Kojima, and Koji Nonogaki.
    • Department of Gastroenterology, Daido Hospital, Japan.
    • Intern. Med. 2024 May 30.

    AbstractWe herein report an unusual case of Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis, and emphasize its unique presentation and diagnostic challenges. Our patient exhibited uncommon symptoms and significant organ involvement, particularly pancreatic enlargement that is not typically associated with ECD. Contrast-enhanced harmonic endoscopic ultrasonography (CEH-EUS) and EUS-fine needle aspiration (EUS-FNA) play crucial roles in the comprehensive assessment of the disease, demonstrating their superiority in identifying and characterizing elusive ECD lesions. This is the first report to document pancreatic lesions in patients with ECD evaluated using CEH-EUS. EUS-FNA is valuable for diagnosing rare diseases, including ECD, with diffuse pancreatic enlargement.

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