• Internal medicine · May 2024

    Repeated Ischemic Stroke due to in situ Thrombus at the Middle Cerebral Artery in a Patient with Essential Thrombocythemia.

    • Toru Nakagami, Yuji Kato, Kaito Watanabe, Ryutaro Kimura, Tsugumi Sato, Takeshi Hayashi, and Satoshi Suda.
    • Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan.
    • Intern. Med. 2024 May 30.

    AbstractEssential thrombocythemia (ET) is a myeloproliferative neoplasm that is a rare cause of ischemic stroke. We herein report a 70-year-old man with JAK2 V617F mutation-positive ET who experienced ischemic stroke twice in 1 month due to transient stenosis. In both events, transient stenosis formed at the same curvature of the right middle cerebral artery, and the thrombus disappeared with the initiation of antiplatelet agents. The formation of in situ thrombus at the curvature of the intracranial vessels may be a unique characteristic of JAK2 V617F mutation-positive ET patients.

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