• Internal medicine · May 2024

    A Case of Primary Adrenal Insufficiency Triggered by Cytomegalovirus Infection after Obinutuzumab plus Bendamustine Therapy for Follicular Lymphoma.

    • Takashi Nakamura, Hideki Uryu, Ryutaro Kawashima, Mizuki Ishiguro, Mika Tanizawa, Yasushi Kanazawa, Hiroyuki Yamazaki, and Yuichi Yahagi.
    • Department of Hematology, Kawaguchi Municipal Medical Center, Japan.
    • Intern. Med. 2024 May 30.

    AbstractA 69-year-old man was diagnosed with follicular lymphoma (Grade 3A). Obinutuzumab combined with bendamustine (OB) therapy was initiated as salvage chemotherapy. Nausea, abdominal pain, and hyponatremia appeared after six courses of OB therapy; cytomegalovirus (CMV) enteritis with primary adrenal insufficiency (PAI) was a complication. Ganciclovir and hydrocortisone were administered, and the clinical findings improved. PAI caused by CMV infection has mainly been reported in patients with acquired immunodeficiency syndrome. In the present case, the PAI triggered by CMV infection led to immunodeficiency after chemotherapy.

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