• Aysel Vehapoglu, Ozden Turel, Serdar Turkmen, Berrin Belcik Inal, Turgut Aksoy, Gamze Ozgurhan, and Murat Ersoy.
• Department of Pediatrics, Bezmialem Vakıf University School of Medicine, Istanbul, Turkey.
• Med Princ Pract. 2015 Jan 1; 24 (4): 332338332-8.

ObjectivesThe aim of this study was to investigate the 25-hydroxyvitamin D [25(OH)D] status of children with growing pains and to evaluate the efficacy of vitamin D treatment on the resolution of pain symptoms.Subjects And MethodsOne hundred and twenty children with growing pains were included in a prospective cohort study. Serum 25(OH)D and bone mineral levels were measured in all subjects at the time of enrollment. The pain intensity of those with vitamin D deficiency was measured using a pain visual analog scale (VAS). After a single oral dose of vitamin D, the pain intensity was remeasured by means of the VAS at 3 months. The 25(OH)D levels and VAS scores before and after oral vitamin D administration were compared by means of a paired Student's t test.ResultsIn the 120 children with growing pains, vitamin D insufficiency was noted in 104 (86.6%). Following vitamin D supplementation, the mean 25(OH)D levels increased from 13.4 ± 7.2 to 44.5 ± 16.4 ng/ml, the mean pain VAS score decreased from 6.8 ± 1.9 to 2.9 ± 2.5 cm (a mean reduction of -3.8 ± 2.1, p < 0.001) and the difference was statistically significant.ConclusionSupplementation with oral vitamin D resulted in a significant reduction in pain intensity among these children with growing pains who had hypovitaminosis D.© 2015 S. Karger AG, Basel.

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