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- Nobumi Suzuki, Nariaki Odawara, Gota Fujisawa, Rei Ishibashi, Masahiro Hata, Yukiko Oya, Kenji Tamada, Takeshi Hayashi, Sohei Abe, Yu Miyakawa, Yoku Hayakawa, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Narikazu Boku, and Mitsuhiro Fujishiro.
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
- Intern. Med. 2024 Jun 6.
AbstractTrastuzumab deruxtecan (T-DXd) has demonstrated remarkable efficacy as a third- or later-line chemotherapy for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction adenocarcinomas. However, it may cause pneumonitis, and its efficacy in rare histologies such as gastric adenocarcinoma with enteroblastic differentiation (GAED) remains unclear. A 74-year-old woman with unresectable HER2-positive GAED and lung metastasis received T-DXd as a fifth-line chemotherapy. Treatment was discontinued after 15 cycles owing to drug-induced pneumonitis; however, the patient achieved a sustained complete response for 14 months without subsequent chemotherapy or the exacerbation of pneumonitis. T-DXd was effective in HER2-positive GAED.
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