• Jacob Eifer Møller, Holger Thiele, and Christian Hassager.
• Department of Cardiology, Copenhagen University Hospital, Copenhagen.
• Curr Opin Crit Care. 2024 Aug 1; 30 (4): 392395392-395.

Purpose Of ReviewTo discuss future research themes and study design in cardiogenic shock.Recent FindingsCardiogenic shock research faces multiple challenges, hindering progress in understanding and treating this life-threatening condition. Cardiogenic shock's heterogeneous nature poses challenges in patient selection for clinical trials, potentially leading to variability in treatment responses and outcomes. Ethical considerations arise due to the acuity and severity of the condition, posing challenges in obtaining informed consent and conducting randomized controlled trials where time to treatment is pivotal.SummaryThis review discusses research in this area focusing on the importance of phenotyping patients with cardiogenic shock, based on artificial intelligence, machine learning, and unravel new molecular mechanisms using proteomics and metabolomics. Further, the future research focus in mechanical circulatory support and targeting inflammation is reviewed. Finally, newer trial designs including adaptive platform trials are discussed.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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