• Christiaan L Meuwese, Lex M van Loon, and Dirk W Donker.
• Department of Cardiology, Thorax Center, Erasmus Medical Center, Rotterdam.
• Curr Opin Crit Care. 2024 Aug 1; 30 (4): 340343340-343.

Purpose Of ReviewThe purpose of this review is to explain the value of computational physiological modeling for in-depth understanding of the complex derangements of cardiopulmonary pathophysiology during cardiogenic shock, particularly when treated with temporary mechanical circulatory support (tMCS) devices.Recent FindingsComputational physiological models have evolved in recent years and can provide a high degree of clinical realism in the simulation of cardiogenic shock and related conservative and interventional therapies. These models feature a large spectrum of practically relevant hemodynamic and respiratory parameters tunable to patient-specific disease states as well as adjustable to medical therapies and support device settings. Current applications work in real-time and can operate on an ordinary computer, laptop or mobile device.SummaryThe use of computational physiological models is increasingly appreciated for educational purposes as they help to understand the complexity of cardiogenic shock, especially when sophisticated management of tMCS is involved in addition to multimodal critical care support. Practical implementation of computational models as clinical decision support tools at the bedside is at the horizon but awaits rigorous clinical validation.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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