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- A Eichenberger, L Pontiggia, and J H Beer.
- Departement Innere Medizin, Kantonsspital Baden. adrian.eichenberger@ksb.ch
- Ther Umsch. 2003 Jan 1;60(1):15-8.
AbstractMany randomized trials have shown aspirin as an effective antiplatelet drug for the secondary prevention of cardiovascular events. The NNT (number needed to treat) to prevent 1 vascular event is about 25. The NNH (number needed to harm) inducing one cerebral bleeding is about 1'000, to provoke one severe extracerebral bleeding about 100-200. The primary prevention can be recommended only for high risk patients for cardiovascular events (annual risk of 1-1.5% or more), calculated on the basis of the Framingham data, the Sheffield tables or in analysis of U.S. Preventive Services Task Force. The mechanisms of action, interactions and the "aspirin-resistance" are briefly discussed.
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