• Alexey N Shkarubo, Anna A Ogurtsova, Zalija F Yakupova, Alexandr V Revishchin, Ludmila V Shishkina, Igor N Pronin, Ilia V Chernov, Galina V Pavlova, Alexey E Podoprigora, Mikhail A Shkarubo, Mikhail E Sinelnikov, Arkadiy Ja Velichko, and Vladimir N Nikolenko.
• Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia.
• World Neurosurg. 2024 Aug 1; 188: e631e641e631-e641.

BackgroundNeurosurgical interventions and trauma are common causes of damage to the optic nerve. This determines the relevance of research for solutions aimed at restoration of the nerve's anatomical integrity, electrical conductivity, and subsequently - restoration of its function. Restore a damaged (cut) optic nerve using n. suralis autograft in vivo.MethodsThe experiment involved reconstruction of the optic nerve through injury modulation, graft placement and restored nerve harvest and evaluation. Injury modulation included removal of a fragment of the optic nerve. Autograft harvesting and placement involved resection of a fragment of the sural (sensory) nerve and its subsequent anastomosis in place of the removed fragment of the optic nerve. As an experimental model, a rabbit of the "Burgundy" breed was used. The animal was previously examined for the presence of infectious and other diseases to confirm its health.ResultsFour months post operatively when stimulating the operated right eye, low-amplitude components altered in shape are registered. Thus, signs of mild restoration of electrical conductivity on the treated optic nerve were seen.ConclusionsOur initial experience shows the technical feasibility of reconstructing the optic nerve using an autograft, the possibility of axonal growth through the graft and, in the future, using this method for direct optic nerve reconstruction, as well as a bypass method for damage to the optic nerve with various tumor diseases of the optic nerve, tumors of the chiasmatic-sellar localization, orbital injuries.Copyright © 2024 Elsevier Inc. All rights reserved.

19 keywords...

hide…