• Turk J Med Sci · Jan 2024

    Evaluation of bone health in terms of osteoporosis in adult patients with neuromuscular disease.

    • Özgür Zeliha Karaahmet, Eda Gürçay, Yasemin Tombak Yildizkan, Damla Cankurtaran, Zeynep Tuba Bahtiyarca, and Ebru Umay.
    • Department of Physical Medicine and Rehabilitation, University of Health Sciences, Etlik City Hospital, Ankara, Turkiye.
    • Turk J Med Sci. 2024 Jan 1; 54 (1): 324329324-329.

    Background/AimThere are no current guidelines to help clinicians decide whether patients with adult neuromuscular disease (NMD) should be screened or treated for osteoporosis (OP). This study was undertaken to investigate the presence of OP in patients with various types of NMD and to examine the relationship between OP evaluation parameters and functional status, daily living activities, balance, and ambulation levels.Materials And MethodsThis cross-sectional study included 45 patients with NMDs. The patients were divided into 3 groups, depending on the affected component of the motor unit (neuronopathy group, neuropathy group, and myopathy group). The laboratory and demographic data were recorded from patient files. Functional level, pain, muscular strength, balance, and daily living activity scores were evaluated. The presence of OP was quantified using bone densitometry, fracture history, and biochemical parameters. Clinical findings were correlated with laboratory and dual-energy X-ray absorptiometry (DEXA) findings.ResultsThe mean hip T-score was -1.20, and the mean lumbar spine (L1-L4) T-score was -0.95 in all groups. Six patients with T-score values of -2.5 or below were detected. Vitamin D level was found to be low in all patient groups, especially in the myopathy group, but there was no significant difference (p > 0.05). There was a negative correlation between hip T-score and the frequency of falling (r = -0.604, p = 0.022), while a positive correlation was found between hip T-score and the age at which independent walking was no longer possible (r = 0.900, p = 0.037).ConclusionOP is often overlooked in NMD patients with neurological problems and a high risk of falling. These patients should be screened for bone health and fragility.© TÜBİTAK.

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