• Güzel TanoğluEsraE0000-0002-0909-8935Department of Molecular Biology and Genetics, Hamidiye Institute of Health Sciences, University of Health Sciences, İstanbul, Turkiye.Experimental Medicine Research and Application Center, University of Health Sciences, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Gülizar Hocaoğlu, and Samet Ebinç.
• Department of Molecular Biology and Genetics, Hamidiye Institute of Health Sciences, University of Health Sciences, İstanbul, Turkiye.
• Turk J Med Sci. 2023 Jan 1; 53 (6): 155215641552-1564.

AbstractLong noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are growing. In this review, it is aimed to provide critical information about lncRNAs in PC, including the biological and oncological behaviors of lncRNAs in PC and their potential application in therapeutic strategies and as diagnostic tumor markers.© TÜBİTAK.

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