• Ramadan Sayed Hussein, DayelSalman BinSB0000-0001-9885-2372Department of Dermatology, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., and Othman Abahussein.
• Department of Dermatology, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
• Turk J Med Sci. 2023 Jan 1; 53 (6): 173217371732-1737.

Background/AimAcne vulgaris (AV) is a common inflammatory skin condition associated with psychological and social distress. Its pathogenesis involves factors such as sebaceous hypersecretion and Cutibacterium acnes colonization. Vitamin D plays a crucial role in the pathogenesis of various inflammatory skin disorders, including AV, due to its immunomodulatory effects and involvement in keratinocyte growth and maturity. However, adequate sun exposure is required for optimal vitamin D synthesis. Isotretinoin (IOS), a vitamin A derivative, is a commonly used medication for severe acne, acting by binding to retinoid receptors. It can also form heterodimers with vitamin D receptors, potentially increasing vitamin D catabolism. Previous studies examining the impact of oral IOS on serum vitamin D levels have yielded inconsistent results. Therefore, this study aimed to assess changes in 25-hydroxy (OH) vitamin D serum levels in individuals with severe AV before and after IOS treatment.Materials And MethodsOne hundred patients with severe AV were enrolled, each receiving 0.75 mg/kg IOS treatment daily for 4 months. Serum 25 OH vitamin D levels were measured before, during, and after treatment.ResultsThis study found a significant increase in serum 25 OH vitamin D levels among patients with severe AV following IOS treatment (p < 0.001).ConclusionThis study suggests that AV may negatively impact vitamin D synthesis, but IOS treatment appears to raise vitamin D serum levels in individuals with severe AV. Further research is needed to confirm the potential relationship between AV and vitamin D levels.© TÜBİTAK.

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