• Toru Kubo, Hiroaki Kitaoka, Shigeo Yamanaka, Takayoshi Hirota, Yuichi Baba, Kayo Hayashi, Tatsuo Iiyama, Naoko Kumagai, Katsutoshi Tanioka, Naohito Yamasaki, Yoshihisa Matsumura, Takashi Furuno, Tetsuro Sugiura, and Yoshinori L Doi.
• Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan.
• J. Am. Coll. Cardiol. 2013 Oct 1;62(14):1252-9.

ObjectivesThis study investigated the significance of the serum high-sensitivity cardiac troponin T (hs-cTnT) marker for prediction of adverse events in hypertrophic cardiomyopathy (HCM).BackgroundAlthough serum cardiac troponins as sensitive and specific markers of myocardial injury have become well-established diagnostic and prognostic markers in acute coronary syndrome, the usefulness of hs-cTnT for prediction of cardiovascular events in patients with HCM is unclear.MethodsWe performed clinical evaluation, including measurements of hs-cTnT in 183 consecutive patients with HCM.ResultsOf 183 HCM patients, 99 (54%) showed abnormal hs-cTnT values (>0.014 ng/ml). During a mean follow-up of 4.1 ± 2.0 years, 32 (32%) of the 99 patients in the abnormal hs-cTnT group, but only 6 (7%) of 84 patients with normal hs-cTnT values, experienced cardiovascular events: cardiovascular deaths, unplanned heart failure admissions, sustained ventricular tachycardia, embolic events, and progression to New York Heart Association functional class III or IV status (hazard ratio [HR]: 5.05, p < 0.001). Abnormal hs-cTnT value remained an independent predictor of these cardiovascular events after multivariate analysis (HR: 3.23, p = 0.012). Furthermore, in the abnormal hs-cTnT group, overall risk increased with an increase in hs-cTnT value (HR: 1.89/hs-cTnT 1 SD increase in the logarithmic scale, 95% confidence interval: 1.13 to 3.15; p = 0.015 [SD: 0.59]).ConclusionsIn patients with HCM, an abnormal serum concentration of hs-cTnT is an independent predictor of adverse outcome, and a higher degree of abnormality in hs-cTnT value is associated with a greater risk of cardiovascular events.Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

54 keywords...

hide…