• Am. J. Med. Sci. · Nov 2024

    Review

    D-dimers in advanced liver cirrhosis: Useful biomarker or not?

    • Lavinia Alice Balaceanu and Ion Dina.
    • Internal Medicine Department, "Carol Davila" University of Medicine and Pharmacy, Emergency Clinical Hospital "Sf. Ioan," Bucharest, Romania. Electronic address: alicebalaceanu@yahoo.com.
    • Am. J. Med. Sci. 2024 Nov 1; 368 (5): 415423415-423.

    AbstractIn clinical practice, the d-dimer levels rule out venous thromboembolism and diagnose disseminated intravascular coagulation. d-dimers increase in both physiological and pathological conditions. Liver cirrhosis, especially in the final stages, is characterized by complex coagulation and fibrinolysis factor disorders. Multiple mechanisms tried to explain the increased d-dimer levels in patients with liver cirrhosis and ascites. The d-dimer cut-off level used to rule out venous thromboembolism in cirrhosis is higher than that used to confirm the diagnosis of VTE or DIC in noncirrhotic patients. The cut-off d-dimer level used for the prognosis of thrombotic events is not standardized in advanced liver cirrhosis. Thus, it is necessary to update the clinical guidelines regarding the usefulness of d-dimer testing in advanced liver cirrhosis and the cut-off d-dimer levels, which should vary based on the detection method.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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