• Elaine Aparecida da Cunha Lima, Luana Vieira Toledo, Marisa Dibbern Lopes Correia, Daniela de Almeida Pereira, Renata Oliveira Caetano, Thaís Bitencourt Faria, de Castro MouraCarolineCDepartment of Medicin... more e and Nursing. Federal University of Viçosa, Viçosa, Brazil., Paula Krempser, and Luciene Muniz Braga. less
• Department of Medicine and Nursing. Federal University of Viçosa, Viçosa, Brazil. Electronic address: elaine.aparecida@ufv.br.
• Pain Manag Nurs. 2025 Feb 1; 26 (1): e18e23e18-e23.

BackgroundAcute pain during vaccine administration is an expected event; however, some strategies, such as the use of high frequency vibration devices associated with cryotherapy, may minimize it.AimEvaluate the effect of high frequency vibration associated with cryotherapy on the level of pain related to the administration of influenza vaccine by intramuscular route in adults.MethodA randomized clinical trial was conducted with 350 adults who received the influenza vaccine. Participants allocated to the intervention group used a high-frequency vibration device associated with cryotherapy during vaccination, and those in the control group administered the vaccine according to the service routine.ResultsMean self-reported pain after vaccination of participants who used the device was lower (1.5 ±1.7) when compared to those who did not use it (1.9 ±1.9) (p = .041). There was an association of higher levels of pain after vaccination with participants in the control group (p = .011), females (p = .042), with higher level of pain expected with vaccination (p < .001) and higher level of anxiety before (p < .001) and after vaccination (p = .001).ConclusionsThe use of high frequency vibration associated with cryotherapy has been shown to be a viable non-pharmacological intervention for the reduction of pain associated with influenza vaccination in adults.Copyright © 2024 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.

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