• Tamblyn Devoy and Natalie Smith.
• Department of Anaesthetics, Wollongong Hospital, Wollongong.
• Curr Opin Anaesthesiol. 2024 Aug 1; 37 (4): 338343338-343.

Purpose Of ReviewThis review article explores the evidence regarding sugammadex (MSD Australia) and its potential interaction with hormonal contraceptives. The impact of recent clinical trials and review articles is examined.Recent FindingsRecent clinical data suggest that the interaction between sugammadex and estrogen and progesterone concentrations may not be clinically significant and may confer some protection against ovulation. There are no clinical trials reporting interactions between sugammadex and the exogenous hormonal compounds found in oral contraceptive pills. The method of contraception is an important consideration, as sugammadex theoretically affects oral and nonoral, and combined versus single agent methods differently. Two large retrospective database studies have reported two cases of pregnancy postoperatively in patients on hormonal contraceptives whose anesthetic included sugammadex.SummaryStrong clinical evidence to support or refute claims of a significant impact of sugammadex on contraceptive efficacy in women on contraception is lacking. The existing evidence does not suggest a basis for concern regarding the impact of sugammadex on contraception in the perioperative setting.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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