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Case Reports
Serotonin Syndrome After Prolonged Remifentanil and Propofol Infusion for Craniotomy: A Case Report.
- Emmad W Kabil, Nadia Lunardi, William G Tennant, and Kamilla Esfahani.
- From the Department of Anesthesiology, University of Virginia.
- A A Pract. 2024 Jun 1; 18 (6): e01793e01793.
AbstractSerotonin syndrome (SS) is a life-threatening condition caused by serotonergic medications. We describe a unique case of SS likely caused by prolonged exposure to propofol and remifentanil alone. A young male presented for vestibular schwannoma resection. Several hours into the case, the patient demonstrated hyperthermia and hemodynamic instability, followed by clonus, rigidity, shivering, and tachycardia after emergence. SS was diagnosed using Hunter's criteria and improved with supportive measures. While the patient endorsed a history of methamphetamine use, his urine drug screen was negative. The possibility of SS should be considered when administering propofol and remifentanil, particularly with prolonged infusions.Copyright © 2024 International Anesthesia Research Society.
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