• Mo Li, Ji-Hui Lyu, Yi Zhang, Mao-Long Gao, Wen-Jie Li, and Xin Ma.
• Center for Cognitive Disorders Department of Scientific Research and Teaching The Geriatric Institute for Clinic and Rehabilitation, Beijing Geriatric Hospital Center of the Treatment in Depressive Disorders, Beijing Anding Hospital, Capital Medical University Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China.
• Medicine (Baltimore). 2017 Dec 1; 96 (51): e9381e9381.

IntroductionAlzheimer disease (AD) is one of the most common diseases among the older adults. Currently, various nonpharmacological interventions are used for the treatment of AD. Such as reminiscence therapy is being widely used in Western countries. However, it is often used as an empirical application in China; the evidence-based efficacy of reminiscence therapy in AD patients remains to be determined. Therefore, the aim of this research is to assess the effectives of reminiscence therapy for Chinese elderly.Methods And AnalysisThis is a randomized parallel-design controlled trial. Mild and moderate AD patients who are in the Beijing Geriatric Hospital, China will be randomized into control and intervention groups (n = 45 for each group). For the intervention group, along with conventional drug therapy, participants will be exposed to a reminiscence therapy of 35 to 45 minutes, 2 times/wk for 12 consecutive weeks. Patients in the control group will undergo conventional drug therapy only. The primary outcome measure will be the differences in Alzheimer disease Assessment Scale-Cognitive Section Score. The secondary outcome measures will be the differences in the Cornell scale for depression in dementia, Neuropsychiatric Inventory score, and Barthel Index scores at baseline, at 4 and 12 weeks of treatment, and 12 weeks after treatment.Ethics And DisseminationThe protocols have been approved by the ethics committee of Beijing Geriatric Hospital of China (approval no. 2015-010). Findings will be disseminated through presentation at scientific conferences and in academic journals.Trial RegistrationChinese Clinical Trial Registry identifier ChiCTR-INR-16009505.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

20 keywords...

hide…