• Alina Mariela Murgu, Irina Geanina Crişcov, Silvia Fotea, Ginel Baciu, Anca Chiriac, Elena Tarca, and Violeta Streanga.
• University of Medicine and Pharmacy "Gr. T. Popa" Pediatric Department "St. Mary" Clinical Emergency Children Hospital, Iasi Children Hospital-ICU, Neonatology Department University of Medicine Galati, Galaţi Dermatology Department, Apolonia University Nicolina Medical Center Petru Poni Institute of Macromolecular Center Chemistry Pediatric Surgery Department, Iasi, Romania.
• Medicine (Baltimore). 2017 Dec 1; 96 (51): e9387e9387.

RationaleCollodion baby is a rare autosomal recessive disorder. It can be the first expression of some forms of ichthyosis.Patient ConcernsThe authors present the case of a newborn diagnosed with severe Collodion baby syndrome who required prolonged hospitalization in the intensive care unit because of infectious complications like the fungal sepsis and other bacterial superinfections.DiagnosesThe case has many diagnostic and therapeutic particularities and management difficulties. Skin culture, dermatological and genetic exam were required.InterventionsThe treatment required multidisciplinary involvement: neonatologist, pediatrician, geneticist, dermatologist, psychologist, ophthalmologist, audiologist.OutcomesThe evolution during hospitalization was slowly favorable, but later, after a few months, it developed some complications.LessonsIn our case, skin injuries, total parenteral nutrition, aggressive and prolonged antibiotic therapy, intravenous devices, high hospitalization duration were risk factors for colonization and sepsis with fungi, especially in the neonatal period, sometimes with severe evolution and prognosis.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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