• Leizhou Xia, Zhitao Li, Pengcheng Jiang, Yongjun Zhang, Xuefeng Bu, and Nana Meng.
• Department of General Surgery, Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, China.
• Medicine (Baltimore). 2024 Jun 7; 103 (23): e38466e38466.

RationaleSclerosing angiomatoid nodular transformation (SANT) of the spleen is an uncommon benign vascular lesion with an obscure etiology. It predominantly affects middle-aged women and presents with nonspecific clinical signs, making preoperative diagnosis challenging. The definitive diagnosis of SANT relies on pathological examination following splenectomy. This study aims to contribute to the understanding of SANT by presenting a case series and reviewing the literature to highlight the clinical presentation, diagnostic challenges, and treatment outcomes.Patient ConcernsIn this retrospective study, we analyzed the clinical data of 3 patients with confirmed SANT admitted from November 2013 to October 2023. The cases include a 25-year-old male, a 15-year-old female, and a 39-year-old male, each with a splenic mass.Diagnoses And InterventionsAll of the three cases were treated by laparoscopic splenectomy (LS). Pathological examination confirmed SANT in all cases.OutcomesNo recurrence or metastasis was observed during a 10-year follow-up for the first 2 cases, and the third case showed no abnormalities at 2 months postoperatively. Despite its rarity, SANT is a significant condition due to its potential for misdiagnosis and the importance of distinguishing it from malignant lesions. The study underscores the utility of LS as a safe and effective treatment option.LessonsSANT is a rare benign tumor of the spleen, and the preoperative diagnosis of whom is challenging. LS is a safe and effective treatment for SANT, with satisfactory surgical outcomes and favorable long-term prognosis on follow-up. The study contributes to the limited body of research on this rare condition and calls for larger studies to validate these findings and improve clinical management.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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