• Yi Yang, Jiajia Jiang, Yajing Liu, Shuanghao Feng, and Hui Bu.
• Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
• Medicine (Baltimore). 2024 Jun 7; 103 (23): e37853e37853.

RationaleNasopharyngeal carcinoma has a high incidence in East and Southeast Asia, often with distant metastasis. However, leptomeningeal metastasis (LM) is extremely rare and usually has a poor prognosis. This paper reports the clinical treatment of a patient with meningeal metastasis of nasopharyngeal carcinoma (NPC) in order to improve the clinician's understanding of the disease. Early diagnosis of the disease can alleviate the pain of patients and prolong their survival time.Patient ConcernsWe report the case of a 55-year-old female with a history of NPC with LM. Brain magnetic resonance imaging showed temporal lobe enhancement, peripheral edema, and enhancement of the adjacent meninges. Cerebrospinal fluid cytology suggests the presence of malignant tumor cells.DiagnosesThe patient was diagnosed with LM from NPC.InterventionsThe patients were regularly given targeted therapy with nimotuzumab, immunotherapy with karyolizumab, and lumbar intrathecal methotrexate chemotherapy and supportive treatment.OutcomesThe patient had survived for 3 years since the diagnosis of LM and was in good condition and still under active antitumor treatment.LessonsLeptomeningeal metastasis of NPC is a rare disease. Although there is currently no unified treatment plan, the neurological symptoms can still be controlled and the quality of life can be improved through active treatment.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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