• Menghe Chen, Zitao Liu, Kai Zheng, Chaohua Hu, and Pai Peng.
• School of Medicine, Wuhan University of Science and Technology, Wuhan, People's Republic of China.
• Medicine (Baltimore). 2024 Jun 7; 103 (23): e38434e38434.

BackgroundTriple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis, and the outcomes of common therapy were not favorable.MethodsThe samples of 84 patients with TNBC and 40 patients with breast fibroadenoma were collected in the pathology department specimen library of our hospital. The prognosis of patients was obtained through outpatient follow-up information, telephone and WeChat contacts, and medical records. The mRNA expression was analyzed using bioinformation and quantitative real-time polymerase chain reaction (qPCR). The protein expression was determined by hematoxylin-eosin staining and immunohistochemical staining. The results of survival analysis were visualized using Kaplan-Meier curves.ResultsThe immunohistochemical staining showed that hypoxia-inducible factor-1alpha (HIF-1α) was mainly distributed in the nucleus and cytoplasm, while CD147 is mainly distributed in cell membrane and cytoplasm. The qPCR results exhibited that the expression level of HIF-1α and CD147 in TNBC tissue was significantly higher than that in breast fibroadenoma tissue. The expression of HIF-1α was related to the histological grade and lymph node metastasis in TNBC, and the expression of CD147 was related to Ki-67, histological grade and lymph node metastasis. There was a positive relationship between the expression of CD147 and HIF-1α. The upregulated expression of CD147 was closely related to the poor prognosis of OS in TNBC.ConclusionCD147 could be a biomarker for the prognosis of TNBC and closely related to the expression of HIF-1α.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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